The Transgenic and Gene Targeting Shared Resource Lab is dedicated to generating mouse transgenic and knockout models for researchers within our Institute. 

Technologies based on both classical transgenesis (via homologous recombination) and gene editing (via CRISPR-Cas9) are exploited to generate mouse models. 

Genes can then either be expressed or inactivated in a development- and tissue-specific manner to understand specific gene function and regulation. Genetic mouse model generation goes from engineering targeting vectors to introducing foreign genetic material into the recipient’s genome through homologous recombination.