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Publications 2019

  1. Aarts S, Reiche M, den Toom M, Gijbels M, Beckers L, Gerdes N, Lutgens E. Depletion of CD40 on CD11c(+) cells worsens the metabolic syndrome and ameliorates hepatic inflammation during NASH. Sci Rep 2019; 9(1): 14702. https://www.ncbi.nlm.nih.gov/pubmed/31604965
  2. Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E. Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis. J Pathol 2019; 247(4): 471-480. https://www.ncbi.nlm.nih.gov/pubmed/30471110
  3. Adrover JM, Del Fresno C, Crainiciuc G, Cuartero MI, Casanova-Acebes M, Weiss LA, Huerga-Encabo H, Silvestre-Roig C, Rossaint J, Cossio I, Lechuga-Vieco AV, Garcia-Prieto J, Gomez-Parrizas M, Quintana JA, Ballesteros I, Martin-Salamanca S, Aroca-Crevillen A, Chong SZ, Evrard M, Balabanian K, Lopez J, Bidzhekov K, Bachelerie F, Abad-Santos F, Munoz-Calleja C, Zarbock A, Soehnlein O, Weber C, Ng LG, Lopez-Rodriguez C, Sancho D, Moro MA, Ibanez B, Hidalgo A. A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. Immunity 2019; 50(2): 390-402 e310. https://www.ncbi.nlm.nih.gov/pubmed/30709741
  4. Bartelt A, Leipsic J, Weber C. The new age of radiomic risk profiling: perivascular fat at the heart of the matter. Eur Heart J 2019; 40(43): 3544-3546. https://www.ncbi.nlm.nih.gov/pubmed/31605139
  5. Bekkering S, Stiekema LCA, Bernelot Moens S, Verweij SL, Novakovic B, Prange K, Versloot M, Roeters van Lennep JE, Stunnenberg H, de Winther M, Stroes ESG, Joosten LAB, Netea MG, Riksen NP. Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia. Cell Metab 2019; 30(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/31204280
  6. Beldman TJ, Malinova TS, Desclos E, Grootemaat AE, Misiak ALS, van der Velden S, van Roomen C, Beckers L, van Veen HA, Krawczyk PM, Hoebe RA, Sluimer JC, Neele AE, de Winther MPJ, van der Wel NN, Lutgens E, Mulder WJM, Huveneers S, Kluza E. Nanoparticle-Aided Characterization of Arterial Endothelial Architecture during Atherosclerosis Progression and Metabolic Therapy. ACS Nano 2019; 13(12): 13759-13774. https://www.ncbi.nlm.nih.gov/pubmed/31268670
  7. Bianchini M, Duchene J, Santovito D, Schloss MJ, Evrard M, Winkels H, Aslani M, Mohanta SK, Horckmans M, Blanchet X, Lacy M, von Hundelshausen P, Atzler D, Habenicht A, Gerdes N, Pelisek J, Ng LG, Steffens S, Weber C, Megens RTA. PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function. Sci Immunol 2019; 4(36). https://www.ncbi.nlm.nih.gov/pubmed/31227596
  8. Bijnen M, van de Gaar J, Vroomen M, Gijbels MJ, de Winther M, Schalkwijk CG, Wouters K. Adipose tissue macrophages do not affect atherosclerosis development in mice. Atherosclerosis 2019; 281: 31-37. https://www.ncbi.nlm.nih.gov/pubmed/30654169
  9. Boeltz S, Amini P, Anders HJ, Andrade F, Bilyy R, Chatfield S, Cichon I, Clancy DM, Desai J, Dumych T, Dwivedi N, Gordon RA, Hahn J, Hidalgo A, Hoffmann MH, Kaplan MJ, Knight JS, Kolaczkowska E, Kubes P, Leppkes M, Manfredi AA, Martin SJ, Maueroder C, Maugeri N, Mitroulis I, Munoz LE, Nakazawa D, Neeli I, Nizet V, Pieterse E, Radic MZ, Reinwald C, Ritis K, Rovere-Querini P, Santocki M, Schauer C, Schett G, Shlomchik MJ, Simon HU, Skendros P, Stojkov D, Vandenabeele P, Berghe TV, van der Vlag J, Vitkov L, von Kockritz-Blickwede M, Yousefi S, Zarbock A, Herrmann M. To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps. Cell Death Differ 2019; 26(3): 395-408. https://www.ncbi.nlm.nih.gov/pubmed/30622307
  10. Bollenbach A, Cordts K, Hanff E, Atzler D, Choe CU, Schwedhelm E, Tsikas D. Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans. Anal Biochem 2019; 577: 59-66. https://www.ncbi.nlm.nih.gov/pubmed/31028716
  11. Bongiovanni D, Santamaria G, Klug M, Santovito D, Felicetta A, Hristov M, von Scheidt M, Aslani M, Cibella J, Weber C, Moretti A, Laugwitz KL, Peano C, Bernlochner I. Transcriptome Analysis of Reticulated Platelets Reveals a Prothrombotic Profile. Thromb Haemost 2019; 119(11): 1795-1806. https://www.ncbi.nlm.nih.gov/pubmed/31473989
  12. Bosch L, de Haan J, Seijkens T, van Tiel C, Brans M, Pasterkamp G, Lutgens E, de Jager S. Small molecule-mediated inhibition of CD40-TRAF6 reduces adverse cardiac remodelling in pressure overload induced heart failure. Int J Cardiol 2019; 279: 141-144. https://www.ncbi.nlm.nih.gov/pubmed/30612848
  13. Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Rios-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY. A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis. Circ Res 2019; 124(1): 94-100. https://www.ncbi.nlm.nih.gov/pubmed/30582442
  14. Busygina K, Denzinger V, Bernlochner I, Weber C, Lorenz R, Siess W. Btk Inhibitors as First Oral Atherothrombosis-Selective Antiplatelet Drugs? Thromb Haemost 2019; 119(8): 1212-1221. https://www.ncbi.nlm.nih.gov/pubmed/31087308
  15. Cassatella MA, Ostberg NK, Tamassia N, Soehnlein O. Biological Roles of Neutrophil-Derived Granule Proteins and Cytokines. Trends Immunol 2019; 40(7): 648-664. https://www.ncbi.nlm.nih.gov/pubmed/31155315
  16. Centa M, Jin H, Hofste L, Hellberg S, Busch A, Baumgartner R, Verzaal NJ, Lind Enoksson S, Perisic Matic L, Boddul SV, Atzler D, Li DY, Sun C, Hansson GK, Ketelhuth DFJ, Hedin U, Wermeling F, Lutgens E, Binder CJ, Maegdesfessel L, Malin SG. Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability. Circulation 2019; 139(21): 2466-2482. https://www.ncbi.nlm.nih.gov/pubmed/30894016
  17. Chen HJ, Li Yim AYF, Griffith GR, de Jonge WJ, Mannens M, Ferrero E, Henneman P, de Winther MPJ. Meta-Analysis of in vitro-Differentiated Macrophages Identifies Transcriptomic Signatures That Classify Disease Macrophages in vivo. Front Immunol 2019; 10: 2887. https://www.ncbi.nlm.nih.gov/pubmed/31921150
  18. Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Endothelial TGF-beta signalling drives vascular inflammation and atherosclerosis. Nat Metab 2019; 1(9): 912-926. https://www.ncbi.nlm.nih.gov/pubmed/31572976
  19. Ciato D, Li R, Monteserin Garcia JL, Papst L, D'Annunzio S, Hristov M, Tichomirowa MA, Belaya Z, Rozhinskaya L, Buchfelder M, Theodoropoulou M, Paez-Pereda M, Stalla GK. Inhibition of Heat Shock Factor 1 Enhances Repressive Molecular Mechanisms on the POMC Promoter. Neuroendocrinology 2019; 109(4): 362-373. https://www.ncbi.nlm.nih.gov/pubmed/30995664
  20. Cimen I, Yildirim Z, Dogan AE, Yildirim AD, Tufanli O, Onat UI, Nguyen U, Watkins SM, Weber C, Erbay E. Double bond configuration of palmitoleate is critical for atheroprotection. Mol Metab 2019; 28: 58-72. https://www.ncbi.nlm.nih.gov/pubmed/31422082
  21. Cordts K, Grzybowski R, Lezius S, Luneburg N, Atzler D, Neu A, Hornig S, Boger RH, Gerloff C, Magnus T, Thomalla G, Schwedhelm E, Grant PJ, Choe CU. Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies. J Neurol Sci 2019; 397: 156-161. https://www.ncbi.nlm.nih.gov/pubmed/30640152
  22. Cossio I, Lucas D, Hidalgo A. Neutrophils as regulators of the hematopoietic niche. Blood 2019; 133(20): 2140-2148. https://www.ncbi.nlm.nih.gov/pubmed/30898859
  23. Cremer S, Michalik KM, Fischer A, Pfisterer L, Jae N, Winter C, Boon RA, Muhly-Reinholz M, John D, Uchida S, Weber C, Poller W, Gunther S, Braun T, Li DY, Maegdefessel L, Perisic Matic L, Hedin U, Soehnlein O, Zeiher A, Dimmeler S. Hematopoietic Deficiency of the Long Noncoding RNA MALAT1 Promotes Atherosclerosis and Plaque Inflammation. Circulation 2019; 139(10): 1320-1334. https://www.ncbi.nlm.nih.gov/pubmed/30586743
  24. de Juan A, Ince LM, Pick R, Chen CS, Molica F, Zuchtriegel G, Wang C, Zhang D, Druzd D, Hessenauer MET, Pelli G, Kolbe I, Oster H, Prophete C, Hergenhan SM, Albrecht U, Ripperger J, Montanez E, Reichel CA, Soehnlein O, Kwak BR, Frenette PS, Scheiermann C. Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins. Circulation 2019; 140(13): 1100-1114. https://www.ncbi.nlm.nih.gov/pubmed/31401849
  25. de Winther MPJ, Dallinga-Thie GM. Introduction to the thematic review series on different levels of genetic regulation of cardiovascular disease. Atherosclerosis 2019; 281: 148-149. https://www.ncbi.nlm.nih.gov/pubmed/30658843
  26. de Winther MPJ, Glass CK. Leducq Epigenetics of Atherosclerosis Network. Circ Res 2019; 124(12): 1697-1700. https://www.ncbi.nlm.nih.gov/pubmed/31170047
  27. de Winther MPJ, Lutgens E. The Link between Hematopoiesis and Atherosclerosis. N Engl J Med 2019; 380(19): 1869-1871. https://www.ncbi.nlm.nih.gov/pubmed/31067380
  28. Dekkers KF, Neele AE, Jukema JW, Heijmans BT, de Winther MPJ. Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites. Epigenetics Chromatin 2019; 12(1): 34. https://www.ncbi.nlm.nih.gov/pubmed/31171035
  29. Denisov SS, Ippel JH, Heinzmann ACA, Koenen RR, Ortega-Gomez A, Soehnlein O, Hackeng TM, Dijkgraaf I. Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2. J Biol Chem 2019; 294(33): 12370-12379. https://www.ncbi.nlm.nih.gov/pubmed/31235521
  30. Denzinger V, Busygina K, Jamasbi J, Pekrul I, Spannagl M, Weber C, Lorenz R, Siess W. Optimizing Platelet GPVI Inhibition versus Haemostatic Impairment by the Btk Inhibitors Ibrutinib, Acalabrutinib, ONO/GS-4059, BGB-3111 and Evobrutinib. Thromb Haemost 2019; 119(3): 397-406. https://www.ncbi.nlm.nih.gov/pubmed/30685871
  31. Doring Y, van der Vorst EPC, Duchene J, Jansen Y, Gencer S, Bidzhekov K, Atzler D, Santovito D, Rader DJ, Saleheen D, Weber C. CXCL12 Derived From Endothelial Cells Promotes Atherosclerosis to Drive Coronary Artery Disease. Circulation 2019; 139(10): 1338-1340. https://www.ncbi.nlm.nih.gov/pubmed/30865486
  32. Eckardt V, Weber C, von Hundelshausen P. Glycans and Glycan-Binding Proteins in Atherosclerosis. Thromb Haemost 2019; 119(8): 1265-1273. https://www.ncbi.nlm.nih.gov/pubmed/31266083
  33. Erdogmus S, Storch U, Danner L, Becker J, Winter M, Ziegler N, Wirth A, Offermanns S, Hoffmann C, Gudermann T, Mederos YSM. Helix 8 is the essential structural motif of mechanosensitive GPCRs. Nat Commun 2019; 10(1): 5784. https://www.ncbi.nlm.nih.gov/pubmed/31857598
  34. Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Doring Y, Nahrendorf M, Kupatt C, Soehnlein O. Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. J Am Coll Cardiol 2019; 73(23): 2990-3002. https://www.ncbi.nlm.nih.gov/pubmed/31196457
  35. Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thoele J, Siuda D, Soehnlein O, Wittig I, Heidler J, Weigert A, Fleming I. Myeloid-Specific Deletion of the AMPKalpha2 Subunit Alters Monocyte Protein Expression and Atherogenesis. Int J Mol Sci 2019; 20(12): 3005. https://www.ncbi.nlm.nih.gov/pubmed/31248224
  36. Garcia-Culebras A, Duran-Laforet V, Pena-Martinez C, Moraga A, Ballesteros I, Cuartero MI, de la Parra J, Palma-Tortosa S, Hidalgo A, Corbi AL, Moro MA, Lizasoain I. Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke. Stroke 2019; 50(10): 2922-2932. https://www.ncbi.nlm.nih.gov/pubmed/31451099
  37. Gencer S, van der Vorst EPC, Aslani M, Weber C, Doring Y, Duchene J. Atypical Chemokine Receptors in Cardiovascular Disease. Thromb Haemost 2019; 119(4): 534-541. https://www.ncbi.nlm.nih.gov/pubmed/30716778
  38. Goldmann L, Duan R, Kragh T, Wittmann G, Weber C, Lorenz R, von Hundelshausen P, Spannagl M, Siess W. Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (FcgammaRIIA): a new option in HIT? Blood Adv 2019; 3(23): 4021-4033. https://www.ncbi.nlm.nih.gov/pubmed/31809536
  39. Gonzalez-Ramos S, Paz-Garcia M, Rius C, Del Monte-Monge A, Rodriguez C, Fernandez-Garcia V, Andres V, Martinez-Gonzalez J, Lasuncion MA, Martin-Sanz P, Soehnlein O, Bosca L. Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1. FASEB J 2019; 33(3): 3912-3921. https://www.ncbi.nlm.nih.gov/pubmed/30496704
  40. Guillamat Prats R, Rami M, Ring L, Rinne P, Lauer E, Lenglet S, Thomas A, Pagano S, Vuilleumier N, Cravatt BF, Weber C, Faussner A, Steffens S. Deficiency of Monoacylglycerol Lipase Enhances IgM Plasma Levels and Limits Atherogenesis in a CB2-Dependent Manner. Thromb Haemost 2019; 119(2): 348-351. https://www.ncbi.nlm.nih.gov/pubmed/30609444
  41. Guillamat-Prats R, Rami M, Herzig S, Steffens S. Endocannabinoid Signalling in Atherosclerosis and Related Metabolic Complications. Thromb Haemost 2019; 119(4): 567-575. https://www.ncbi.nlm.nih.gov/pubmed/30769363
  42. Hackler E, 3rd, Lew J, Gore MO, Ayers CR, Atzler D, Khera A, Rohatgi A, Lewis A, Neeland I, Omland T, de Lemos JA. Racial Differences in Cardiovascular Biomarkers in the General Population. J Am Heart Assoc 2019; 8(18): e012729. https://www.ncbi.nlm.nih.gov/pubmed/31514563
  43. Hidalgo A, Chilvers ER, Summers C, Koenderman L. The Neutrophil Life Cycle. Trends Immunol 2019; 40(7): 584-597. https://www.ncbi.nlm.nih.gov/pubmed/31153737
  44. Hollander MR, Jansen MF, Hopman L, Dolk E, van de Ven PM, Knaapen P, Horrevoets AJ, Lutgens E, van Royen N. Stimulation of Collateral Vessel Growth by Inhibition of Galectin 2 in Mice Using a Single-Domain Llama-Derived Antibody. J Am Heart Assoc 2019; 8(20): e012806. https://www.ncbi.nlm.nih.gov/pubmed/31594443
  45. Hu D, Yin C, Luo S, Habenicht AJR, Mohanta SK. Vascular Smooth Muscle Cells Contribute to Atherosclerosis Immunity. Front Immunol 2019; 10: 1101. https://www.ncbi.nlm.nih.gov/pubmed/31164888
  46. Joppich M, Weber C, Zimmer R. Using Context-Sensitive Text Mining to Identify miRNAs in Different Stages of Atherosclerosis. Thromb Haemost 2019; 119(8): 1247-1264. https://www.ncbi.nlm.nih.gov/pubmed/31378854
  47. Ketelhuth DFJ, Lutgens E, Back M, Binder CJ, Van den Bossche J, Daniel C, Dumitriu IE, Hoefer I, Libby P, O'Neill L, Weber C, Evans PC. Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res 2019; 115(9): 1385-1392. https://www.ncbi.nlm.nih.gov/pubmed/31228191
  48. Kiouptsi K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C, Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C, Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P, Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der Vorst EPC, Doring Y, Reinhardt C. The Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. mBio 2019; 10(5): e02298-02219. https://www.ncbi.nlm.nih.gov/pubmed/31641089
  49. Koenen RR. Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease. Thromb Haemost 2019; 119(8): 1202-1204. https://www.ncbi.nlm.nih.gov/pubmed/31266081
  50. Kornhuber KTI, Seidel H, Pujol C, Meierhofer C, Roschenthaler F, Pressler A, Stockl A, Nagdyman N, Neidenbach RC, von Hundelshausen P, Halle M, Holdenrieder S, Ewert P, Kaemmerer H, Hauser M. Hemostatic abnormalities in adult patients with Marfan syndrome. Cardiovasc Diagn Ther 2019; 9(Suppl 2): S209-S220. https://www.ncbi.nlm.nih.gov/pubmed/31737529
  51. Lacy M, Atzler D, Liu R, de Winther M, Weber C, Lutgens E. Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis. Pharmacol Ther 2019; 193: 50-62. https://www.ncbi.nlm.nih.gov/pubmed/30149100
  52. Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Bluher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab 2019; 30(4): 768-783 e767. https://www.ncbi.nlm.nih.gov/pubmed/31353262
  53. Lip GYH, Weber C. Thrombosis and Haemostasis Wishes You a Happy New Year Ahead! Thromb Haemost 2019; 119(1): 1-2. https://www.ncbi.nlm.nih.gov/pubmed/30597493
  54. Luque-Martin R, Van den Bossche J, Furze RC, Neele AE, van der Velden S, Gijbels MJJ, van Roomen C, Bernard SG, de Jonge WJ, Rioja I, Prinjha RK, Lewis HD, Mander PK, de Winther MPJ. Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis. Front Pharmacol 2019; 10: 1242. https://www.ncbi.nlm.nih.gov/pubmed/31736752
  55. Lutgens E. Epigenetic Quenching of VSMC Inflammation in CVD: H3K9me2 in Control. Arterioscler Thromb Vasc Biol 2019; 39(11): 2199-2200. https://www.ncbi.nlm.nih.gov/pubmed/31644350
  56. Lutgens E, Atzler D, Doring Y, Duchene J, Steffens S, Weber C. Immunotherapy for cardiovascular disease. Eur Heart J 2019; 40(48): 3937-3946. https://www.ncbi.nlm.nih.gov/pubmed/31121017
  57. Mauler M, Hilgendorf I, Duerschmied D. Response by Mauler et al to Letter Regarding Article, "Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation". Circulation 2019; 140(7): e292-e293. https://www.ncbi.nlm.nih.gov/pubmed/31403846
  58. Meeuwsen JAL, de Vries JJ, van Duijvenvoorde A, van der Velden S, van der Laan SW, van Koeverden ID, van de Weg SM, de Borst GJ, de Winther MPJ, Kuiper J, Pasterkamp G, Hoefer IE, de Jager SCA, Queen of Hearts C. Circulating CD14(+)CD16(-) classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients. J Mol Cell Cardiol 2019; 127: 260-269. https://www.ncbi.nlm.nih.gov/pubmed/30629987
  59. Nagy M, van Geffen JP, Stegner D, Adams DJ, Braun A, de Witt SM, Elvers M, Geer MJ, Kuijpers MJE, Kunzelmann K, Mori J, Oury C, Pircher J, Pleines I, Poole AW, Senis YA, Verdoold R, Weber C, Nieswandt B, Heemskerk JWM, Baaten C. Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis. Front Cardiovasc Med 2019; 6: 99. https://www.ncbi.nlm.nih.gov/pubmed/31417909
  60. Natarelli L, Weber C. Next-Generation Therapeutic Concepts for Atherosclerosis: Focus on Cell Specificity and Noncoding RNAs. Thromb Haemost 2019; 119(8): 1199-1201. https://www.ncbi.nlm.nih.gov/pubmed/31378853
  61. Neidhart M, Pajak A, Laskari K, Riksen NP, Joosten LAB, Netea MG, Lutgens E, Stroes ESG, Ciurea A, Distler O, Grigorian M, Karouzakis E. Oligomeric S100A4 Is Associated With Monocyte Innate Immune Memory and Bypass of Tolerance to Subsequent Stimulation With Lipopolysaccharides. Front Immunol 2019; 10: 791. https://www.ncbi.nlm.nih.gov/pubmed/31037071
  62. Ng LG, Ostuni R, Hidalgo A. Heterogeneity of neutrophils. Nat Rev Immunol 2019; 19(4): 255-265. https://www.ncbi.nlm.nih.gov/pubmed/30816340
  63. Nicorescu I, Dallinga GM, de Winther MPJ, Stroes ESG, Bahjat M. Potential epigenetic therapeutics for atherosclerosis treatment. Atherosclerosis 2019; 281: 189-197. https://www.ncbi.nlm.nih.gov/pubmed/30340764
  64. Nitz K, Lacy M, Atzler D. Amino Acids and Their Metabolism in Atherosclerosis. Arterioscler Thromb Vasc Biol 2019; 39(3): 319-330. https://www.ncbi.nlm.nih.gov/pubmed/30650999
  65. Noels H, Weber C, Koenen RR. Chemokines as Therapeutic Targets in Cardiovascular Disease. Arterioscler Thromb Vasc Biol 2019; 39(4): 583-592. https://www.ncbi.nlm.nih.gov/pubmed/30760014
  66. Onat UI, Yildirim AD, Tufanli O, Cimen I, Kocaturk B, Veli Z, Hamid SM, Shimada K, Chen S, Sin J, Shah PK, Gottlieb RA, Arditi M, Erbay E. Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis. J Am Coll Cardiol 2019; 73(10): 1149-1169. https://www.ncbi.nlm.nih.gov/pubmed/30871699
  67. Paloschi V, Winter H, Viola J, Soehnlein O, Maegdefessel L. Mechanistic Links between Non-Coding RNAs and Myeloid Cell Inflammation in Atherosclerosis. Thromb Haemost 2019; 119(8): 1205-1211. https://www.ncbi.nlm.nih.gov/pubmed/31035303
  68. Pfeiler S, Thakur M, Grunauer P, Megens RTA, Joshi U, Coletti R, Samara V, Muller-Stoy G, Ishikawa-Ankerhold H, Stark K, Klingl A, Frohlich T, Arnold GJ, Wormann S, Bruns CJ, Algul H, Weber C, Massberg S, Engelmann B. CD36-triggered cell invasion and persistent tissue colonization by tumor microvesicles during metastasis. FASEB J 2019; 33(2): 1860-1872. https://www.ncbi.nlm.nih.gov/pubmed/30207797
  69. Pfeiler S, Winkels H, Kelm M, Gerdes N. IL-1 family cytokines in cardiovascular disease. Cytokine 2019; 122: 154215. https://www.ncbi.nlm.nih.gov/pubmed/29198612
  70. Puhl SL, Steffens S. Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution? Front Cardiovasc Med 2019; 6: 25. https://www.ncbi.nlm.nih.gov/pubmed/30937305
  71. Puhl SL, Weeks KL, Guran A, Ranieri A, Boknik P, Kirchhefer U, Muller FU, Avkiran M. Role of type 2A phosphatase regulatory subunit B56alpha in regulating cardiac responses to beta-adrenergic stimulation in vivo. Cardiovasc Res 2019; 115(3): 519-529. https://www.ncbi.nlm.nih.gov/pubmed/30203051
  72. Rasmuson J, Kenne E, Wahlgren M, Soehnlein O, Lindbom L. Heparinoid sevuparin inhibits Streptococcus-induced vascular leak through neutralizing neutrophil-derived proteins. FASEB J 2019; 33(9): 10443-10452. https://www.ncbi.nlm.nih.gov/pubmed/31216421
  73. Reiche ME, den Toom M, Willemsen L, van Os B, Gijbels MJJ, Gerdes N, Aarts S, Lutgens E. Deficiency of T cell CD40L has minor beneficial effects on obesity-induced metabolic dysfunction. BMJ Open Diabetes Res Care 2019; 7(1): e000829. https://www.ncbi.nlm.nih.gov/pubmed/31908798
  74. Sager HB, Husser O, Steffens S, Laugwitz KL, Schunkert H, Kastrati A, Ndrepepa G, Kessler T. Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction. J Transl Med 2019; 17(1): 180. https://www.ncbi.nlm.nih.gov/pubmed/31142323
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