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Publications 2012

  1. Bampalis VG, Brantl SA, Siess W. Why and how to eliminate spontaneous platelet aggregation in blood measured by multiple electrode aggregometry. J Thromb Haemost 2012; 10(8): 1710-1714. https://www.ncbi.nlm.nih.gov/pubmed/22712617
  2. Bidzhekov K, Gan L, Denecke B, Rostalsky A, Hristov M, Koeppel TA, Zernecke A, Weber C. microRNA expression signatures and parallels between monocyte subsets and atherosclerotic plaque in humans. Thromb Haemost 2012; 107(4): 619-625. https://www.ncbi.nlm.nih.gov/pubmed/22370758
  3. Blanchet X, Langer M, Weber C, Koenen RR, von Hundelshausen P. Touch of chemokines. Front Immunol 2012; 3: 175. https://www.ncbi.nlm.nih.gov/pubmed/22807925
  4. Bras G, Bochenska O, Rapala-Kozik M, Guevara-Lora I, Faussner A, Kozik A. Extracellular aspartic protease SAP2 of Candida albicans yeast cleaves human kininogens and releases proinflammatory peptides, Met-Lys-bradykinin and des-Arg(9)-Met-Lys-bradykinin. Biol Chem 2012; 393(8): 829-839. https://www.ncbi.nlm.nih.gov/pubmed/22944684
  5. Brauner R, Johannes C, Ploessl F, Bracher F, Lorenz RL. Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor alpha activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. J Nutr 2012; 142(6): 981-989. https://www.ncbi.nlm.nih.gov/pubmed/22535758
  6. Cardilo-Reis L, Gruber S, Schreier SM, Drechsler M, Papac-Milicevic N, Weber C, Wagner O, Stangl H, Soehnlein O, Binder CJ. Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med 2012; 4(10): 1072-1086. https://www.ncbi.nlm.nih.gov/pubmed/23027612
  7. Djafarzadeh R, Sauter M, Notohamiprodjo S, Noessner E, Goyal P, Siess W, Wornle M, Ribeiro A, Himmelein S, Sitter T, Nelson PJ. Recombinant GPI-anchored TIMP-1 stimulates growth and migration of peritoneal mesothelial cells. PLoS One 2012; 7(4): e33963. https://www.ncbi.nlm.nih.gov/pubmed/22558080
  8. Doring Y, Drechsler M, Wantha S, Kemmerich K, Lievens D, Vijayan S, Gallo RL, Weber C, Soehnlein O. Lack of neutrophil-derived CRAMP reduces atherosclerosis in mice. Circ Res 2012; 110(8): 1052-1056. https://www.ncbi.nlm.nih.gov/pubmed/22394519
  9. Doring Y, Manthey HD, Drechsler M, Lievens D, Megens RT, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E, Zenke M, Binder CJ, Weber C, Zernecke A. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 2012; 125(13): 1673-1683. https://www.ncbi.nlm.nih.gov/pubmed/22388324
  10. Doring Y, Noels H, Weber C. The use of high-throughput technologies to investigate vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 2012; 32(2): 182-195. https://www.ncbi.nlm.nih.gov/pubmed/22258901
  11. Doring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, Zernecke A. Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 2012; 32(7): 1613-1623. https://www.ncbi.nlm.nih.gov/pubmed/22556330
  12. Doring Y, Zernecke A. Plasmacytoid dendritic cells in atherosclerosis. Front Physiol 2012; 3: 230. https://www.ncbi.nlm.nih.gov/pubmed/22754539
  13. Egea V, Schober A, Weber C. Circulating miRNAs: messengers on the move in cardiovascular disease. Thromb Haemost 2012; 108(4): 590-591. https://www.ncbi.nlm.nih.gov/pubmed/22955179
  14. Egea V, Zahler S, Rieth N, Neth P, Popp T, Kehe K, Jochum M, Ries C. Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A 2012; 109(6): E309-316. https://www.ncbi.nlm.nih.gov/pubmed/22223664
  15. Faussner A, Schussler S, Feierler J, Bermudez M, Pfeifer J, Schnatbaum K, Tradler T, Jochum M, Wolber G, Gibson C. Binding characteristics of [3H]-JSM10292: a new cell membrane-permeant non-peptide bradykinin B2 receptor antagonist. Br J Pharmacol 2012; 167(4): 839-853. https://www.ncbi.nlm.nih.gov/pubmed/22646218
  16. Grismayer B, Sato S, Kopitz C, Ries C, Soelch S, Schmitt M, Baretton G, Kruger A, Luther T, Kotzsch M, Magdolen V. Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes. Biol Chem 2012; 393(12): 1449-1455. https://www.ncbi.nlm.nih.gov/pubmed/23667902
  17. Grommes J, Alard JE, Drechsler M, Wantha S, Morgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O. Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med 2012; 185(6): 628-636. https://www.ncbi.nlm.nih.gov/pubmed/22246174
  18. Grommes J, Morgelin M, Soehnlein O. Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment. Eur Respir J 2012; 40(2): 416-423. https://www.ncbi.nlm.nih.gov/pubmed/22267758
  19. Grommes J, Vijayan S, Drechsler M, Hartwig H, Morgelin M, Dembinski R, Jacobs M, Koeppel TA, Binnebosel M, Weber C, Soehnlein O. Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. PLoS One 2012; 7(6): e38917. https://www.ncbi.nlm.nih.gov/pubmed/22701728
  20. Hamesch K, Subramanian P, Li X, Dembowsky K, Chevalier E, Weber C, Schober A. The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation without impairing re-endothelialisation. Thromb Haemost 2012; 107(2): 356-368. https://www.ncbi.nlm.nih.gov/pubmed/22234341
  21. Hristov M, Schmitz S, Nauwelaers F, Weber C. A flow cytometric protocol for enumeration of endothelial progenitor cells and monocyte subsets in human blood. J Immunol Methods 2012; 381(1-2): 9-13. https://www.ncbi.nlm.nih.gov/pubmed/22537800
  22. Kamchybekov U, Figulla HR, Gerdes N, Jung C. Macrophage migration inhibitory factor is elevated in obese adolescents. Arch Physiol Biochem 2012; 118(4): 204-209. https://www.ncbi.nlm.nih.gov/pubmed/22676646
  23. Kanzler I, Liehn EA, Koenen RR, Weber C. Anti-inflammatory therapeutic approaches to reduce acute atherosclerotic complications. Curr Pharm Biotechnol 2012; 13(1): 37-45. https://www.ncbi.nlm.nih.gov/pubmed/21470163
  24. Karshovska E, Weber C. Atherosclerosis: cell biology and lipoproteins--new mechanistic links in atherosclerosis: chemokines mediating the effects of lipids, platelets and dendritic cells. Curr Opin Lipidol 2012; 23(4): 400-401. https://www.ncbi.nlm.nih.gov/pubmed/22801391
  25. Koenen R, Weber C. Chemokines and Their Receptors as Therapeutic Targets in Atherosclerosis. In: Atherosclerosis: Treatment and Prevention. Pan Stanford Publishing; 2012: 1-30. http://dx.doi.org/10.1201/b13723-2
  26. Kolben T, Perobner I, Fernsebner K, Lechner F, Geissler C, Ruiz-Heinrich L, Capovilla S, Jochum M, Neth P. Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells. Biol Chem 2012; 393(12): 1433-1447. https://www.ncbi.nlm.nih.gov/pubmed/23152409
  27. Liehn EA, Bucur O, Weber C. Role of microparticles as messengers enhancing stem cell activity after genetic engineering. Circ Res 2012; 111(3): 265-267. https://www.ncbi.nlm.nih.gov/pubmed/22821904
  28. Lip GYH, Weber C. Welcome to a new year in Thrombosis and Haemostasis…. Thrombosis and Haemostasis 2012; 107(01): 1-2. http://dx.doi.org/10.1055/s-0037-1608982
  29. Lutgens E, Leiner T, Weber C. RANK(L)-ing biomarkers as surrogates for coronary calcium score. Thromb Haemost 2012; 107(1): 3. https://www.ncbi.nlm.nih.gov/pubmed/22159710
  30. Matusik P, Guzik B, Weber C, Guzik TJ. Do we know enough about the immune pathogenesis of acute coronary syndromes to improve clinical practice? Thromb Haemost 2012; 108(3): 443-456. https://www.ncbi.nlm.nih.gov/pubmed/22872109
  31. Megens RT, Vijayan S, Lievens D, Doring Y, van Zandvoort MA, Grommes J, Weber C, Soehnlein O. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 2012; 107(3): 597-598. https://www.ncbi.nlm.nih.gov/pubmed/22318427
  32. Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest 2012; 122(11): 4190-4202. https://www.ncbi.nlm.nih.gov/pubmed/23041630
  33. Nazari-Jahantigh M, Wei Y, Schober A. The role of microRNAs in arterial remodelling. Thromb Haemost 2012; 107(4): 611-618. https://www.ncbi.nlm.nih.gov/pubmed/22371089
  34. Noels H, Bernhagen J, Weber C. MIF in Atherosclerosis. In: The MIF Handbook. WORLD SCIENTIFIC; 2012: 321-345. http://dx.doi.org/10.1142/9789814335362_0017
  35. Perobner I, Karow M, Jochum M, Neth P. LRP6 mediates Wnt/beta-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells. Int J Biochem Cell Biol 2012; 44(11): 1970-1982. https://www.ncbi.nlm.nih.gov/pubmed/22871567
  36. Postea O, Vasina EM, Cauwenberghs S, Projahn D, Liehn EA, Lievens D, Theelen W, Kramp BK, Butoi ED, Soehnlein O, Heemskerk JW, Ludwig A, Weber C, Koenen RR. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol 2012; 32(5): 1186-1193. https://www.ncbi.nlm.nih.gov/pubmed/22383701
  37. Poti F, Costa S, Bergonzini V, Galletti M, Pignatti E, Weber C, Simoni M, Nofer JR. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R(-)/(-)) mice. Vascul Pharmacol 2012; 57(1): 56-64. https://www.ncbi.nlm.nih.gov/pubmed/22459073
  38. Projahn D, Koenen RR. Platelets: key players in vascular inflammation. J Leukoc Biol 2012; 92(6): 1167-1175. https://www.ncbi.nlm.nih.gov/pubmed/22923486
  39. Raffetseder U, Liehn EA, Weber C, Mertens PR. Role of cold shock Y-box protein-1 in inflammation, atherosclerosis and organ transplant rejection. Eur J Cell Biol 2012; 91(6-7): 567-575. https://www.ncbi.nlm.nih.gov/pubmed/21943779
  40. Redondo S, Gonzalez-Rocafort A, Navarro-Dorado J, Ramajo M, Hristov M, Gordillo-Moscoso A, Reguillo F, Carnero M, Martinez-Gonzalez J, Rodriguez E, Weber C, Tejerina T. Decreased pre-surgical CD34+/CD144+ cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients. J Cardiothorac Surg 2012; 7: 2. https://www.ncbi.nlm.nih.gov/pubmed/22214418
  41. Rohwedder I, Montanez E, Beckmann K, Bengtsson E, Duner P, Nilsson J, Soehnlein O, Fassler R. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med 2012; 4(7): 564-576. https://www.ncbi.nlm.nih.gov/pubmed/22514136
  42. Rowinska Z, Zander S, Zernecke A, Jacobs M, Langer S, Weber C, Merx MW, Koeppel TA. Non- invasive in vivo analysis of a murine aortic graft using high resolution ultrasound microimaging. Eur J Radiol 2012; 81(2): 244-249. https://www.ncbi.nlm.nih.gov/pubmed/21334152
  43. Schober A, Siess W. Lysophosphatidic acid in atherosclerotic diseases. Br J Pharmacol 2012; 167(3): 465-482. https://www.ncbi.nlm.nih.gov/pubmed/22568609
  44. Schuh A, Kroh A, Konschalla S, Liehn EA, Sobota RM, Biessen EA, Bot I, Sonmez TT, Schober A, Marx N, Weber C, Sasse A. Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model. J Cell Mol Med 2012; 16(10): 2311-2320. https://www.ncbi.nlm.nih.gov/pubmed/22288686
  45. Schuh A, Sasse A, Konschalla S, Kroh A, Merx MW, Weber C, Liehn EA. Repetitive transplantation of different cell types sequentially improves heart function after infarction. J Cell Mol Med 2012; 16(7): 1640-1647. https://www.ncbi.nlm.nih.gov/pubmed/22050647
  46. Schwartz V, Kruttgen A, Weis J, Weber C, Ostendorf T, Lue H, Bernhagen J. Role for CD74 and CXCR4 in clathrin-dependent endocytosis of the cytokine MIF. Eur J Cell Biol 2012; 91(6-7): 435-449. https://www.ncbi.nlm.nih.gov/pubmed/22014447
  47. Soehnlein O. Multiple roles for neutrophils in atherosclerosis. Circ Res 2012; 110(6): 875-888. https://www.ncbi.nlm.nih.gov/pubmed/22427325
  48. Soehnlein O, Weber C. Neutrophils and their granule proteins in the treatment of athero-sclerosis. In: Atherosclerosis: Treatment and Prevention. Pan Stanford Publishing; 2012: 1-30. http://dx.doi.org/10.1201/b13723-2
  49. Stoger JL, Gijbels MJ, van der Velden S, Manca M, van der Loos CM, Biessen EA, Daemen MJ, Lutgens E, de Winther MP. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 2012; 225(2): 461-468. https://www.ncbi.nlm.nih.gov/pubmed/23078881
  50. Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S. J Am Chem Soc 2012; 134(47): 19318-19321. https://www.ncbi.nlm.nih.gov/pubmed/23066897
  51. Weber C, Lip GYH. Highlights and hot topics from 2011 in Thrombosis and Haemostasis. Thrombosis and Haemostasis 2012; 107(01): 196-199. http://dx.doi.org/10.1055/s-0037-1608981
  52. Zernecke A, Weber C. Improving the treatment of atherosclerosis by linking anti-inflammatory and lipid modulating strategies. Heart 2012; 98(21): 1600-1606. https://www.ncbi.nlm.nih.gov/pubmed/23086996